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Oxandrolone is also used to decrease muscle loss caused by using steroid medicines, and to reduce bone pain in people with osteoporosis.[9] 2.5 Metabolic Effects Metabolic effects of androgens are often described as 'dopamine-like', referring to the effect of testosterone on the brain and nervous system.[2,10] They are known to increase appetite, reduce appetite, increase sexual desire and improve mood.[11] The effects on mood are thought to be caused by upregulation of the serotonin (5-HT) system[12] acting via a receptor called serotonin receptors 5-HT1A and 5-HT1B.[13] 2.6 Interactions with Other Drugs A large increase in T levels has been reported after use of androgen-deprivation therapy for prostate cancer.[14] 2.7 Safety and Toxicity The safety and efficacy of oral gendalloid analogues has been investigated in small studies, which have not yet provided sufficient evidence to conclude that they are safe.[10,15][16] Long-term studies in healthy human beings have also been unable to detect any adverse side effects, although some individuals have experienced increased gastrointestinal side effects (anorexia and weight loss) associated with these drugs.[17][18] Treatment with testosterone, such as replacement therapy, may result in alterations in blood chemistry. However, studies in animals have not detected any adverse effects,[18][19] and some studies have even observed a beneficial effect.[20][21] The risks associated with the use of gendalloids in men include liver damage and other cardiovascular disturbances. These risks appear to be lower than those in women. 2.8 Other Pharmacological Effects Some agents like aldosterone,[22] 17-keto testosterone,[23] and theophylline[24][25] interact with androgen receptors like androstenedione and testosterone. 3 Pharmacology 3.1. Absorption Anandamide is found in the gut of humans but in much lower levels.[26] The levels of its metabolites are not significantly different between men and women, and both bodybuilders and sedentary individuals, although no significant differences were found.[27] Anandamide appears to be absorbed through the GI tract in a manner similar to other TCA cycle metabolites, but to a much lesser extent than its metabolic metabolite testosterone.[28] A high dose of aldosterone has been reported to cause significant increases in serum anandamide concentrations in both men and women;[ Related Article:

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